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KMID : 0376219930300010073
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Chonnam Medical Journal
1993 Volume.30 No. 1 p.73 ~ p.81
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Comparison of In-vitro Activity of Mupirocin and Other Antibiotics Against Staphylococcus aureus Isolated from Pus
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Chun Inn-Ki
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Abstract
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One hundred seventy-one strains of Staphylococcus aureus isolated from the pus of hospitalized patients in Chonnam National University Hospital, Kwangju Christian Hospital, and Chosun University Hospital were studied for determining their suscep￢tibility to mupirocin, oxacillin, gentamicin, amikacin, tetracycline, erythromycin. ciprofloxacin, fusidic acid, and vancomycin by using agar dilution method.
Sixty-nine strains(40.4%) of S. aureus were susceptible to oxacillin(methicillin) and 102 strains(59.6%) were resistant. MIC range of mupirocin was less than 0.5 mg /ml and that of vancomycin was 0.25-4 mg /ml.
In comparison of MIC90, mupirocin, vancomycin, fusidic acid and ciproflocaxin were highly active with their MIC90 ranging from 0.5 to 2 mg/ml, whereas gentamicin, tetracycline, and erythromycin were less active with their MIC90 ranging from 128 to 512 mg /ml.
All strains were susceptible to mupirocin and vancomycin, and over 90% of strains tested were susceptible to fusidic acid and ciprofloxacin. But, about 70% of strains were resistant to gentamicin, tetracycline, and erythromycin, especially, 90% of methicillin-resistant S. aureus were resistant to gentamicin and erythromycin.
The results indicate that mupirocin may prove useful for treating of skin infections by Staphylococcus aureus including those MRSA.
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